Research Project Title

Global Gene Expression Analysis in the Absence of a Non-Receptor Tyrosine Kinase During Post-Embryonic Development of the Nematode C. elegans

Session Type

Traditional Paper Presentation

Research Project Abstract

FRK-1 is a non-receptor tyrosine kinase that regulates cell proliferation and differentiation during embryonic development of the nematode Caenorhabditis elegans. A frk-1 mutant results in uncoordinated larvae that arrest at the first larval stage. Our previous studies have shown that eliminating frk-1 results in excess hypodermal (skin) cells, which secrete the cuticle-forming components. We further sought to characterize cuticle signaling pathways in the frk-1 mutant by measuring global gene expression using RNA Seq and Functional Enrichment Analysis, and found a large number of collagen genes were significantly affected, suggesting a master regulation of cuticle by FRK-1, during cuticle formation in C. elegans.

Session Number

RS8

Location

Weyerhaueser 303

Abstract Number

RS8-e

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Apr 28th, 11:00 AM Apr 28th, 12:30 PM

Global Gene Expression Analysis in the Absence of a Non-Receptor Tyrosine Kinase During Post-Embryonic Development of the Nematode C. elegans

Weyerhaueser 303

FRK-1 is a non-receptor tyrosine kinase that regulates cell proliferation and differentiation during embryonic development of the nematode Caenorhabditis elegans. A frk-1 mutant results in uncoordinated larvae that arrest at the first larval stage. Our previous studies have shown that eliminating frk-1 results in excess hypodermal (skin) cells, which secrete the cuticle-forming components. We further sought to characterize cuticle signaling pathways in the frk-1 mutant by measuring global gene expression using RNA Seq and Functional Enrichment Analysis, and found a large number of collagen genes were significantly affected, suggesting a master regulation of cuticle by FRK-1, during cuticle formation in C. elegans.