Approaches to the Organic Synthesis of 2-Oxoglutaramate
Faculty Sponsor
Travis T. Denton, PhD.
Session Type
Poster Presentation
Research Project Abstract
2-Oxoglutaramate (OGM) is related to 2-oxoglutarate (OG), a highly characterized intermediate of the TCA cycle and glutaminolysis. Understanding OGM in biological systems is crucial for understanding the metabolism of 2-hydroxyglutarate (HG), an oncometabolite present in high levels in people with L-2-HG aciduria, caused by a rare inborn error of metabolism. Previously, studying OGM has been limited by the absence of a method for its synthesis in pure form. This research intended to develop a method to synthesize OGM from OG using organic techniques. Using a three-step synthesis approach, various monosubstituted OG, disubstituted OGM and monosubstituted OGM compounds were synthesized, purified and characterized. This approach to synthesize a library of OGM analogues provides new tools to study mitochondrial metabolism as it relates to cancer and neurological diseases. Optimized synthesis techniques for OGM analogues will expedite future development for the synthesis of OGM.
Session Number
PS1
Location
HUB Multipurpose Room
Abstract Number
PS1-w
Approaches to the Organic Synthesis of 2-Oxoglutaramate
HUB Multipurpose Room
2-Oxoglutaramate (OGM) is related to 2-oxoglutarate (OG), a highly characterized intermediate of the TCA cycle and glutaminolysis. Understanding OGM in biological systems is crucial for understanding the metabolism of 2-hydroxyglutarate (HG), an oncometabolite present in high levels in people with L-2-HG aciduria, caused by a rare inborn error of metabolism. Previously, studying OGM has been limited by the absence of a method for its synthesis in pure form. This research intended to develop a method to synthesize OGM from OG using organic techniques. Using a three-step synthesis approach, various monosubstituted OG, disubstituted OGM and monosubstituted OGM compounds were synthesized, purified and characterized. This approach to synthesize a library of OGM analogues provides new tools to study mitochondrial metabolism as it relates to cancer and neurological diseases. Optimized synthesis techniques for OGM analogues will expedite future development for the synthesis of OGM.
