Research Project Title

Approaches to the Organic Synthesis of 2-Oxoglutaramate

Session Type

Poster Presentation

Research Project Abstract

2-Oxoglutaramate (OGM) is related to 2-oxoglutarate (OG), a highly characterized intermediate of the TCA cycle and glutaminolysis. Understanding OGM in biological systems is crucial for understanding the metabolism of 2-hydroxyglutarate (HG), an oncometabolite present in high levels in people with L-2-HG aciduria, caused by a rare inborn error of metabolism. Previously, studying OGM has been limited by the absence of a method for its synthesis in pure form. This research intended to develop a method to synthesize OGM from OG using organic techniques. Using a three-step synthesis approach, various monosubstituted OG, disubstituted OGM and monosubstituted OGM compounds were synthesized, purified and characterized. This approach to synthesize a library of OGM analogues provides new tools to study mitochondrial metabolism as it relates to cancer and neurological diseases. Optimized synthesis techniques for OGM analogues will expedite future development for the synthesis of OGM.

Session Number

PS1

Location

HUB Multipurpose Room

Abstract Number

PS1-w

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Apr 28th, 9:15 AM Apr 28th, 10:45 AM

Approaches to the Organic Synthesis of 2-Oxoglutaramate

HUB Multipurpose Room

2-Oxoglutaramate (OGM) is related to 2-oxoglutarate (OG), a highly characterized intermediate of the TCA cycle and glutaminolysis. Understanding OGM in biological systems is crucial for understanding the metabolism of 2-hydroxyglutarate (HG), an oncometabolite present in high levels in people with L-2-HG aciduria, caused by a rare inborn error of metabolism. Previously, studying OGM has been limited by the absence of a method for its synthesis in pure form. This research intended to develop a method to synthesize OGM from OG using organic techniques. Using a three-step synthesis approach, various monosubstituted OG, disubstituted OGM and monosubstituted OGM compounds were synthesized, purified and characterized. This approach to synthesize a library of OGM analogues provides new tools to study mitochondrial metabolism as it relates to cancer and neurological diseases. Optimized synthesis techniques for OGM analogues will expedite future development for the synthesis of OGM.