Characterization of the cyclization of sucralose derivatives under basic conditions.
Faculty Sponsor
Dr. Trisha Russell, PhD
trisharussell@whitworth.edu
Session Type
Poster Presentation
Research Project Abstract
Sucralose (Splenda®) is an artificial sweetener that can be found in a majority of commercial foods, yet very little is known about the possible derivatives of sucralose formed during cooking. In previous studies, a dicyclized derivative has been identified. The goal of this research, is to identify the order of cyclization. To measure the progression of the reaction sucralose was heated in basic water using myo-inositol as an internal standard. By taking out samples at various time points and silylating the alcohol groups, the derivatives formed could be characterized via gas chromatography and mass spectrometry. The results showed that a ring is formed between C7 and the oxygen off C10 producing the monocyclized sucralose derivative intermediate of the reaction followed by a second cyclization to form the dicyclized product.
Session Number
PS1
Location
HUB Multipurpose Room
Abstract Number
PS1-t
Characterization of the cyclization of sucralose derivatives under basic conditions.
HUB Multipurpose Room
Sucralose (Splenda®) is an artificial sweetener that can be found in a majority of commercial foods, yet very little is known about the possible derivatives of sucralose formed during cooking. In previous studies, a dicyclized derivative has been identified. The goal of this research, is to identify the order of cyclization. To measure the progression of the reaction sucralose was heated in basic water using myo-inositol as an internal standard. By taking out samples at various time points and silylating the alcohol groups, the derivatives formed could be characterized via gas chromatography and mass spectrometry. The results showed that a ring is formed between C7 and the oxygen off C10 producing the monocyclized sucralose derivative intermediate of the reaction followed by a second cyclization to form the dicyclized product.
