Research Project Title

Characterization of the cyclization of sucralose derivatives under basic conditions.

Session Type

Poster Presentation

Research Project Abstract

Sucralose (Splenda®) is an artificial sweetener that can be found in a majority of commercial foods, yet very little is known about the possible derivatives of sucralose formed during cooking. In previous studies, a dicyclized derivative has been identified. The goal of this research, is to identify the order of cyclization. To measure the progression of the reaction sucralose was heated in basic water using myo-inositol as an internal standard. By taking out samples at various time points and silylating the alcohol groups, the derivatives formed could be characterized via gas chromatography and mass spectrometry. The results showed that a ring is formed between C7 and the oxygen off C10 producing the monocyclized sucralose derivative intermediate of the reaction followed by a second cyclization to form the dicyclized product.

Session Number

PS1

Location

HUB Multipurpose Room

Abstract Number

PS1-t

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Apr 28th, 9:15 AM Apr 28th, 10:45 AM

Characterization of the cyclization of sucralose derivatives under basic conditions.

HUB Multipurpose Room

Sucralose (Splenda®) is an artificial sweetener that can be found in a majority of commercial foods, yet very little is known about the possible derivatives of sucralose formed during cooking. In previous studies, a dicyclized derivative has been identified. The goal of this research, is to identify the order of cyclization. To measure the progression of the reaction sucralose was heated in basic water using myo-inositol as an internal standard. By taking out samples at various time points and silylating the alcohol groups, the derivatives formed could be characterized via gas chromatography and mass spectrometry. The results showed that a ring is formed between C7 and the oxygen off C10 producing the monocyclized sucralose derivative intermediate of the reaction followed by a second cyclization to form the dicyclized product.