Development of Dual-Modality Liposomes for Image-Guided Drug Delivery Applications
Faculty Sponsor
Osasere Mary Evbuomwan, Gonzaga University
Research Project Abstract
Lanthanide complexes have been widely studied as magnetic resonance imaging (MRI) contrast agents. Several of these complexes have been incorporated into liposomes for MRI-guided drug delivery applications. Although these approaches have taken advantage of the paramagnetic properties of lanthanides, they do not capitalize on their optical properties. The aim of this project is to develop dual-modality liposomes for optical and MRI-guided drug delivery. These liposomes consist of a mixture of organic chromophores and lanthanide complexes that are either core-encapsulated or embedded in the lipid bilayer. We hypothesize that the complexes will give an MRI signal, while the combination of the organic chromophore and the complex will provide an optical signal. Current work involves establishing a liposome formation method as well as synthesizing several polar and amphiphilic lanthanide complexes. Following structure and purity determination, the resulting compounds will be incorporated into liposomes and the optical and MR properties will be investigated.
Session Number
PS2
Location
Graves Gym
Abstract Number
PS2-p
Development of Dual-Modality Liposomes for Image-Guided Drug Delivery Applications
Graves Gym
Lanthanide complexes have been widely studied as magnetic resonance imaging (MRI) contrast agents. Several of these complexes have been incorporated into liposomes for MRI-guided drug delivery applications. Although these approaches have taken advantage of the paramagnetic properties of lanthanides, they do not capitalize on their optical properties. The aim of this project is to develop dual-modality liposomes for optical and MRI-guided drug delivery. These liposomes consist of a mixture of organic chromophores and lanthanide complexes that are either core-encapsulated or embedded in the lipid bilayer. We hypothesize that the complexes will give an MRI signal, while the combination of the organic chromophore and the complex will provide an optical signal. Current work involves establishing a liposome formation method as well as synthesizing several polar and amphiphilic lanthanide complexes. Following structure and purity determination, the resulting compounds will be incorporated into liposomes and the optical and MR properties will be investigated.
